P058  Persistence of neutrophil abnormalities in COVID-19 convalescence

Conclusion Circulating neutrophils in acute COVID-19 have an altered phenotype and comprise immature and activated cells. This altered phenotype persisted in convalescence and may contribute to the persistence of symptoms and an increased susceptibility to subsequent infections. Future work will aim to inve stigate the functional implications of these findings.Disclosure T.O. Williams: None.V. K ästele: None.E.R. Mann: None.S.B. Knight: None.M. Menon: None.C. Jagger: None.S. Khan: None.J.E. Konkel: None.T.N. Shaw: None.M. Rattray: Consultancies; M.R. has a paid consultancy with AstraZeneca.L. Pearmain: None.A. Horsley: None.A. Ustianowski: None.I. Prise: None.N.D. Bakerly: None.P.M. Dark: None.G.M. Lord: Corporate appointments; G.M.L. is cofounder and scientific advisory board member of Gritstone Oncology Inc., which is a public company that develops therapeutic vaccines (primarily for the treatment of cancer).A. Simpson: None.T. Felton: None.L. Ho: None.M. Feldmann: None.I. Bruce: None.J.R. Grainger: None.T. Hussell: None.
Source: Rheumatology - Category: Rheumatology Source Type: research