Decreased expression of programmed death-1 on CD8 + effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes

ConclusionsIt is the first report of the expression of PD-1 on CD8+ Tem cells in T1D in the present study. Our observations suggest that the PD-1/PD-L1 signal pathway on CD8+ Tem cells of T1D subjects might identify a new pathway for delaying the occurrence and development by inhibiting autoimmunity.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research