Differentiation and maintenance of long-lived plasma cells.

Differentiation and maintenance of long-lived plasma cells.
Curr Opin Immunol. 2015 Feb 9;33C:64-69
Authors: Kometani K, Kurosaki T
Abstract
Long-lived plasma cells, which mostly reside in the bone marrow have been shown to be vital for protection from recurrent infections. Recent gene-targeting and cell-ablation experiments have solidified the concept that their survival depends on both cell-intrinsic programs and extrinsic factors. The BTB transcription factor ZBTB20, which is expressed at high levels in long-lived plasma cells, is critical for their survival. On the other hand, eosinophils, megakaryocytes and monocytes function to establish a niche for long-lived plasma cells by secreting cytokines and growth factors such as APRIL and IL6.
PMID: 25677584 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - February 9, 2015 Category: Allergy & Immunology Authors: Kometani K, Kurosaki T Tags: Curr Opin Immunol Source Type: research