A balancing act between primate lentiviruses and their receptor [Microbiology]

The receptor for primate lentiviruses, including HIV-1, is the CD4 glycoprotein found on myeloid and T helper cells. CD4 also plays a critical role in mediating adaptive immune responses and in immune cell differentiation by coordinating interactions between T cell receptors and major histocompatibility complex (MHC) proteins (1). This sets...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Microbiology, Commentaries Commentary Source Type: research