Single-step direct drug provocation testing is safe for de-labelling selected “non-low-risk” penicillin allergy labels

Penicillin allergy labels are prevalent, and removal of incorrect labels improves patient outcomes and health economics. Labels may be classified as "low-risk", or "non-lowrisk", the latter chiefly where symptoms suggest IgE-mediated etiology. Traditionally, "non-low-risk" allergy labels are assessed by penicillin skin testing followed by graded multi-step penicillin drug provocation testing (DPT).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research