Evaluation of glucagon-like peptide-1 receptor expression in non-diabetic and diabetic atherosclerotic mice using PET tracer < sup > 68 < /sup > Ga-NODAGA-exendin-4

In conclusion, 68Ga-NODAGA-exendin-4 detects GLP-1R expression in atherosclerotic lesions in both non-diabetic and diabetic hypercholesterolemic mice. These results provide evidence that GLP-1R expression is mainly localized in macrophage-rich area in atherosclerotic lesions and may have implications for studies of pharmacological modification of GLP-1R signaling in atherosclerosis.PMID:33843281 | DOI:10.1152/ajpendo.00465.2020

Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Mia St åhle Sanna Hellberg Jenni Virta Heidi Liljenb äck Olli Mets älä Xiang-Guo Li Matti Jauhiainen Pekka Saukko Seppo Yl ä-Herttuala Pirjo Nuutila Juhani Knuuti Antti Saraste Anne Roivainen Source Type: research