Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone

Although atrial fibrillation ablation is increasingly used for rhythm control therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination with ablation. The effectiveness of AADs is highly variable. Previous work from our group suggests that alterations in atrial resting membrane potential (RMP) induced by low Pitx2 expression could explain the variable effect of flecainide.

Source: Heart Rhythm - March 15, 2021 Category: Cardiology Authors: Andrew P. Holmes, Priyanka Saxena, S. Nashitha Kabir, Christopher O ’Shea, Stefan M. Kuhlmann, Suranjana Gupta, Dannie Fobian, Clara Apicella, Molly O’Reilly, Fahima Syeda, Jasmeet S. Reyat, Godfrey L. Smith, Antony J. Workman, Davor Pavlovic, Larissa Source Type: research