Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity

Recent efforts attempted to include individual patient genetic data in Normal Tissue Complication Probability (NTCP) models [1,2]. As with any predictive model, a clinically useful genetic-based NTCP model requires a sufficient number of common variants, given that each likely has a small effect on risk of complications. Radiogenomic studies are finding an increasing number of common (i.e. seen in>1% of the population) single nucleotide polymorphisms (SNPs) that can be combined to derive a polygenic risk score (PRS).

Source: Radiotherapy and Oncology - April 7, 2021 Category: Radiology Authors: Nicola Rares Franco, Michela Carlotta Massi, Francesca Ieva, Andrea Manzoni, Anna Maria Paganoni, Paolo Zunino, Liv Veldeman, Piet Ost, Val érie Fonteyne, Christopher J. Talbot, Tim Rattay, Adam Webb, Kerstie Johnson, Maarten Lambrecht, Karin Haustermans Tags: Original Article Source Type: research