The role of androgen receptors in vascular and cell proliferation of the prostate adenocarcinomas

In this study, we analyzed the immunoexpression of androgen receptor (AR), cluster of differentiation 105 (CD105) and Ki67 for 61 cases of PA, in relation to the main clinicopathological parameters of the lesions. The AR scores, CD105 microvessel density (MVD) and Ki67 proliferation index (PI) were significantly higher in patients with serum prostate-specific antigen (PSA) above 20 ng∕mL, in ductal, colloid and sarcomatoid types of PA, in growth patterns 4-5 or mixed, respectively in the case of high-grade advanced stage tumors, with perineural and vascular invasion, as well as in groups with a reserved prognosis. The results obtained, reflected in the positive linear correlation of AR, CD105 and Ki67 expression, indicate synchronous endocrine, angiogenic and proliferative mechanisms involved in tumor progression, which can be used to optimize the targeted tumor therapy.PMID:33817721 | DOI:10.47162/RJME.61.3.18

Source: Romanian Journal of Morphology and Embryology - April 5, 2021 Category: General Medicine Authors: Andrei P ănuş Claudiu M ărgăritescu Petru Octavian Dr ăgoescu Paul Ioan Tomescu Mihai Lucian Ştefănescu Alex Emilian Stepan Source Type: research