Resveratrol improves granulosa cell activity through mitochondrial biogenesis

Granulosa cells (GC) support the developing oocyte from its earliest primordial follicle stage, playing an essential role in oocyte maturation and human reproduction. These important cells provide energy for oocyte follicular maturation through carbohydrate, lipid, and protein metabolism (1). The energy needed by the oocyte is provided in the form of adenosine triphosphate, which is produced in the granulosa cell mitochondria and passed to the oocyte via gap junctions. Hence, the mitochondria serve a critical role in energy production for the growing oocyte.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research