Insulin detemir is transported from blood to cerebrospinal fluid and has prolonged central anorectic action relative to NPH insulin.

Insulin detemir is transported from blood to cerebrospinal fluid and has prolonged central anorectic action relative to NPH insulin. Diabetes. 2015 Feb 9; Authors: Begg DP, May AA, Mul JD, Liu M, D'Alessio DA, Seeley RJ, Woods SC Abstract Insulin detemir (DET) reduces glycemia comparably to other long-acting insulin formulations, but causes less weight-gain. Insulin-signaling in the brain is catabolic, reducing food intake. We hypothesized that DET reduces weight-gain, relative to other insulins, due to increased transport into the central nervous system and/or increased catabolic action within the brain. Transport of DET and NPH insulin (NPH) into the cerebrospinal fluid (CSF) was compared over several hours and following the administration of different doses peripherally in rats. DET and NPH had comparable saturable, receptor-mediated transport into the CSF. CSF insulin remained elevated significantly longer following ip DET than following NPH. When administered acutely into the 3rd-cerebral ventricle, both DET and NPH insulin reduced food intake and body weight at 24-h, and both food intake and body weight remained lower following DET than following NPH after 48-h. In direct comparison with another long-acting insulin, insulin glargine (GLAR), DET led to more prolonged increases in CSF insulin despite a shorter plasma half-life in both rats and mice. Additionally, peripheral DET administration reduced weight gain and increased CSF...
Source: Diabetes - Category: Endocrinology Authors: Tags: Diabetes Source Type: research