Effect of GHS-R deletion on growth, pulsatile GH secretion and meal pattern in male and female mice

Conclusion. These results point to a sex-dependent dimorphic effect of GHS-R1a signaling to modulate pulsatile GH secretion and meal pattern in mice with different compensatory mechanisms occuring in the hypothalamus of adult males and females after GHS-R1a deletion. Altogether, we show that GHS-R1a signaling plays a more critical role in the regulation of pulsatile GH secretion during adolescence in males and adulthood in females.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research