Examining the intubation decision in randomised clinical trials

Tobin et al. [1] pointed in their editorial to the limitations of randomised trials in determining the effect of noninvasive modalities on the intubation of patients with respiratory failure. My colleagues and I have recently examined many design aspects of 53 randomised trials that evaluated the effect of noninvasive ventilation and high flow oxygen therapy on the outcomes of patients with acute respiratory failure [2]. Our findings support many of the points highlighted in the editorial.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research