246 Nephrotic Syndrome in patient with Lyme Disease: Case Report

Publication date: April 2021Source: American Journal of Kidney Diseases, Volume 77, Issue 4Author(s):
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

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is the most common tick-borne illness in the USA and Europe. Pathogens involved include Borrelia burgdorferi in the USA and B. afzelii and B. garinii in Europe. The characteristic rash of erythema migrans occurs in 70 –80% of patients. Neurological disease, including facial palsy, meningo-encephalitis, aseptic meningitis and polyradiculopathy, occurs in 10–15%. Cardiac disease, primarily manifest as heart block, is seen in 1–4%. Arthritis is a late complication in about 30% of untreated patients.
Source: Medicine - Category: Internal Medicine Authors: Tags: Bacterial infections Source Type: research
This study aimed to investigate the crosstalk between PLA2R activation and mTOR signaling in a human podocyte cell line. We demonstrated that podocyte apoptosis was induced by Group IB secretory phospholipase A2 (sPLA2IB) in a concentration- and time-dependent manner via upregulation of phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and mTOR, and inhibited by rapamycin or LY294002. Furthermore, aberrant activation of the PI3K/AKT/mTOR pathway triggers both extrinsic (caspase-8 and caspase-3) and intrinsic (Bcl-2-associated X protein [BAX], B-cell lymphoma 2 [BCL-2], cytochrome c, caspase-9, and caspase-3) apopto...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
J Proteome Res. 2021 Oct 26. doi: 10.1021/acs.jproteome.1c00516. Online ahead of print.ABSTRACTDepression is a common psychopathological state or mood disorder syndrome. The serious risks to human life and the inadequacy of the existing antidepressant drugs have driven us to understand the pathogenesis of depression from a new perspective. Our research group has found disturbances in glucose catabolism in both depression and nephrotic syndrome. What are the specific metabolic pathways and specificities of glucose catabolism disorders caused by depression? To address the above scientific questions, we creatively combined tr...
Source: Cell Research - Category: Cytology Authors: Source Type: research
AbstractGlomerular IgM deposition is commonly shown in idiopathic membranous nephropathy, but the clinicopathological features and outcomes of IMN with IgM deposition are unclear. This single-center prospective cohort study enrolled 210 patients with biopsy-proven IMN from January 2016 to December 2018. Clinicopathological features, treatment responses, and kidney outcomes were compared between patients with and without IgM deposition. In total, 76 (36.2%) patients show glomerular IgM deposition. Patients with IgM deposition were younger (45  ± 13.30 vs. 50.59 ± 13.65 years,P&...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
The Infectious Diseases Society of America (IDSA) could have chosen to settle the lawsuit instead of fighting it, but the principles at stake were too high, they decided.Medscape Medical News
Source: Medscape Rheumatology Headlines - Category: Rheumatology Tags: Infectious Diseases News Source Type: news
This report describes how a student and nursing faculty member provided community education to 3 rural communities about how climate change impacts the health of rural communities through the local community newspaper serving the 3 communities. Climate and health-related topics in a weekly newspaper column in this project included extreme heat events, Lyme disease, air pollution, water quality, soil health, environmental justice, and the role of the nurse in planetary health.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Brief Report Source Type: research
AbstractPurpose of ReviewWe highlight the unique facets of paediatric nephrology in Africa in terms of the spectrum of kidney diseases, available diagnostic and treatment modalities, kidney healthcare financing options, paediatric nephrology manpower and the contribution of geography and demographics.Recent FindingsPaediatric acute kidney injury in Africa is now commonly due to sepsis rather than gastroenteritis. Steroid-sensitive form of nephrotic syndrome is far more common than was two decades ago.SummaryThe hot arid climate in North Africa and the tropical climate in most of sub-Saharan Africa, and the high rate of con...
Source: Current Pediatrics Reports - Category: Pediatrics Source Type: research
CONCLUSIONS: Patients with untreated or uncontrolled PV could have massive proteinuria and advanced CKD, pathologically showing ischemic, sclerosing glomerular lesions with hypercellurity, glomerular crescents and endocapillary proliferation. IgA nephropathy was most commonly diagnosed. These findings deserve attention because early screening and effective control of PV may benefit the long-term kidney prognosis.PMID:34687616 | DOI:10.1016/j.amjms.2021.10.009
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Source Type: research
The association between the COVID vaccine and MCD is temporal and by exclusion, and it is not fully established, but it should be considered in post-vaccine MCD. AbstractThe association between the COVID vaccine and MCD is temporal and by exclusion, and it is not fully established, but it should be considered in postvvaccine MCD.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
AbstractLyme disease is an infection caused byBorrelia burgdorferi sensu lato, which is transmitted to humans through the bite of an infected Ixodes tick. The majority of patients recover without complications with antibiotic therapy. However, for a minority of patients, accompanying non-specific symptoms can persist for months following completion of therapy. The constellation of symptoms such as fatigue, cognitive dysfunction, and musculoskeletal pain that persist beyond 6  months and are associated with disability have been termed post-treatment Lyme disease syndrome (PTLDS), a subset of a broader term “chron...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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