Chromo-fluorogenic sensors for chemical warfare agents in real-time analysis: journey towards accurate detection and differentiation

Chem Commun (Camb). 2021 Mar 16. doi: 10.1039/d1cc00132a. Online ahead of print.ABSTRACTThe existence of chemical weapons (blister and nerve agents) is an unfortunate reality of the modern world. The usage of these chemical agents by rogue states or terrorist groups has showcased their ugly faces in the past and even in recent years. Despite extensive and strenuous efforts by the Organization for the Prohibition of Chemical Weapons (OPCW) to eliminate chemical warfare agents (CWAs) by the prohibition of their production and the destruction of their stockpiles, many countries still possess them in enormous quantities. Given the potential threat from these lethal agents, it is imperative to have a foolproof chemical sensor and detection system, which should consist of readily deployable chemical probes that can operate with high specificity and sensitivity. Over the last decade, our group has been engaged in designing and developing novel field-deployable sensing techniques by exploring approaches based on supramolecular tools, which can result in excellent specificity, sensitivity, high speed, portability and low cost. In this article, I describe our group's journey and success stories in the development of chemical warfare detection protocols, detailing the range of unique chemical probes and methods explored to achieve the specific detection of individual agents under real environmental conditions. It is interesting to note that the combination of three molecular probes (SQ,...
Source: Chemical Communications - Category: Chemistry Authors: Source Type: research