Cerebrovascular development: mechanisms and experimental approaches

Cell Mol Life Sci. 2021 Mar 10. doi: 10.1007/s00018-021-03790-1. Online ahead of print.ABSTRACTThe cerebral vasculature plays a central role in human health and disease and possesses several unique anatomic, functional and molecular characteristics. Despite their importance, the mechanisms that determine cerebrovascular development are less well studied than other vascular territories. This is in part due to limitations of existing models and techniques for visualisation and manipulation of the cerebral vasculature. In this review we summarise the experimental approaches used to study the cerebral vessels and the mechanisms that contribute to their development.PMID:33688979 | DOI:10.1007/s00018-021-03790-1

Source: Cellular and Molecular Life Sciences : CMLS - March 10, 2021 Category: Cytology Authors: Timothy J A Chico Elisabeth C Kugler Source Type: research