T-lymphoblastic leukemia/lymphoma with interfollicular growth pattern and Castleman-like morphologic features

We present an unusual T-LBL/L in a lymph node mimicking iT-LBP. The case showed preserved nodal architecture, morphologic features of hyaline vascular Castleman disease, proliferation of T-lymphoblasts in the interfollicular area, and no clonal T-cell receptor gene rearrangement. The follow-up lymph node specimen excised 6 months later showed full-blown lymphoblastic lymphoma with an abnormal karyotype, near-early-T-precursor phenotype, partial CD19 expression, andSETD2 mutation.
Source: Journal of Hematopathology - Category: Pathology Source Type: research