Standardized microfluidic assessment of red blood cell –mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease

ConclusionsWe demonstrated that RBC ‐mediated microcapillary occlusion and OI associated with subject clinical phenotype and HU responsiveness in SCD. The presented standardized microfluidic assay may be useful for evaluating clinical phenotype and assessing therapeutic outcomes in SCD, including emerging targeted and curative treat ments that aim to improve RBC deformability and microcirculatory health.

Source: Microcirculation - March 1, 2021 Category: Research Authors: Yuncheng Man, Erdem Kucukal, Ran An, Allison Bode, Jane A. Little, Umut A. Gurkan Tags: ORIGINAL RESEARCH Source Type: research