Scientists will test whether gout drug helps infected adults beat Covid symptoms

Oxford University researchers have begun trials on 30p pill colchicine today to examine whether it can reduce recovery time from Covid and prevent the need for hospital admission.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Probenecid, a drug used to treat gout, has shown anti-viral capabilities, a study from the University of Georgia finds. It is among a variety of drugs being tested to treat COVID-19.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsOnly two cases with initial endocarditis prior to AOSD diagnosis have been published, and we are not aware of any other cases reporting - β1AR-Ab development with DCM and gout in the setting of AOSD treated with anakinra.
Source: European Journal of Medical Research - Category: Research Source Type: research
September is Rheumatic Disease Awareness Month, which makes this a good time to learn about four common rheumatic diseases: ankylosing spondylitis, gout, juvenile idiopathic arthritis and lupus. Ankylosing spondylitis Ankylosing spondylitis is an inflammatory disease that can cause some of the small bones in your spine to fuse. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it can be difficult to breathe deeply. Ankylosing spondylitis…
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
As you probably know, the FDA recently approved a monoclonal antibody called aducanumab as a treatment for Alzheimer's disease. To make a long story short, there's no good evidence that it actually has any effect on dementia; the approval is based on its effectiveness in removing abnormal plaques of a protein called beta-amyloid from the brain. These are associated with Alzheimer's disease, but there's no evidence that they cause it, or that removing them improves symptoms. Aducanumab can also have some very troubling adverse effects such as brain swelling. Oh yeah -- Biogen plans to charge $56,000/year for the treatment.&...
Source: Stayin' Alive - Category: American Health Source Type: blogs
Gout is the most frequent form of inflammatory arthritis in the world. Its prevalence is particularly elevated in specific geographical areas such as in the Oceania/Pacific region and is rising in the US, Europe, and Asia. Gout is a severe and painful disease, in which co-morbidities are responsible for a significant reduction in life expectancy. However, gout patients remain ostracized because the disease is still considered “self-inflicted”, as a result of unhealthy lifestyle and excessive food and alcohol intake. While the etiology of gout flares is clearly associated with the presence of monosodium urate (M...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: The recommendations in this consensus document are provided to assist clinicians in the selection of CPM-HA products, administration techniques and depths of injection with the aim of providing seamless and natural treatment results, enhanced safety and patient satisfaction.PMID:34526796 | PMC:PMC8435881 | DOI:10.2147/CCID.S311017
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Authors: Source Type: research
In conclusion, we successfully demonstrated that the ε2 haplotype, but not the ε4 haplotype, incre ases SUA levels. These findings will improve our understanding of genetic factors affecting SUA levels.
Source: Human Cell - Category: Cytology Source Type: research
Conclusion: This is the first study on changes in brain cortical thickness and SCN based on graph theory in patients with gout. The present study found that, compared with healthy controls, gout patients show regional cortical thinning or thickening, and variation in the properties of the cortical thickness covariance network also changed. These alterations may be the combined effect of disease damage and physiological compensation. More research is needed to fully understand the complex underlying mechanisms of gout brain variation.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ObjectiveTo clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout.MethodsWe retrospectively analyzed 237 male gout patients who had two sets of body composition and metabolic measurements within 6 months. Subjects included had all been treated with urate-lowering therapy (ULT) (febuxostat 20–80 mg/day or benzbromarone 25–50 mg/day, validated by the medical record). All patients were from the specialty gout clinic of The Affiliated Hospital of Qingdao University. The multiple linear regression model evaluated the relationship between change in SU [...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
THE UNPRECEDENTED scale of the vaccine rollout has proven an effective shield against infection. For those who do become infected and become seriously ill, however, current go-to treatments are massively limited. One new study has suggested the gout drug remdesivir could be a prime candidate to treat severely ill COVID-19 patients.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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