Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP

This study presents the crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP at 2.58   Å resolution. The results demonstrate that buffer components can interfere with the characterization of cysteine-dependent inhibitor compounds.

Source: Acta Crystallographica Section F - March 3, 2021 Category: Biochemistry Authors: Shaikhqasem, A. Schmitt, K. Valerius, O. Ficner, R. Tags: nuclear export cancer exportin 1 cysteine modification research communications Source Type: research