Two decades of research towards a potential first anti-epileptic drug

Antiepileptogenesis, the process by which one would be able to prevent a “normal” brain from becoming epileptic, has been a Holy Grail in epileptology for more than 3 decades [1–3]. While the concept of epileptogenesis has been strongly influenced by using the kindling model [4,5], drugs capable of altering kindling rate (epileptogenesis) often failed when tested i n clinical settings [6,7]).

Source: Seizure: European Journal of Epilepsy - March 2, 2021 Category: Neurology Authors: Simone Kastropil Benassi, Julieta Goncalves Silva Macedo Alves, Cristiane Gorgatti Guidoreni, Cristina Gon çalves Massant, Claudio M Queiroz, Emilio Garrido-Sanabria, Rafael Duarte de Souza Loduca, Maria Alice Susemihl, Wellingson Silva Paiva, Almir Ferr Source Type: research