PAS domains in bacterial signal transduction

Curr Opin Microbiol. 2021 Feb 26;61:8-15. doi: 10.1016/j.mib.2021.01.004. Online ahead of print.ABSTRACTPAS domains are widespread, versatile domains found in proteins from all kingdoms of life. The PAS fold is composed of an antiparallel β-sheet with several flanking α-helices, and contains a conserved cleft for cofactor or ligand binding. The last few years have seen a prodigious increase in identified PAS domains and resolved PAS structures, including structures with effector and other domains. New bacterial PAS ligands have been discovered, and structure-function studies have improved our understanding of PAS signaling mechanisms. The list of bacterial PAS functions has now expanded to include roles in signal sensing, modulation, transduction, dimerization, protein interaction, and cellular localization.PMID:33647528 | DOI:10.1016/j.mib.2021.01.004

Source: Current Opinion in Microbiology - March 1, 2021 Category: Microbiology Authors: Erwin C Stuffle Mark S Johnson Kylie J Watts Source Type: research