GSE155679 Repeated stimulation of self-presentation pathway by targeting erythrocytes in vivo drives anergy and profound T cell dysfunction

Contributors : Elyse A Watkins ; Jennifer T Antane ; Andrew C Tremain ; Jaeda L Roberts ; Kristen M Lorentz ; Sarah Zuerndorfer ; Anya C Dunaif ; Luke Bailey ; Mindy Nguyen ; Robert DeLoera ; Stephan Kontos ; Jeffrey A HubbellSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe purpose of this study was to conduct an in-depth analysis of the molecular characteristics of both CD4 and CD8 T cells upon encounter of self-associated antigen bound to erythrocytes, induce therapeutic tolerance in an endogenous repertoire of T cells, and understand the mechanisms involved in uptake and presentation of erythrocyte-associated antigen.

Source: GEO: Gene Expression Omnibus - February 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research