Calcineurin A-alpha suppression drives Nuclear Factor κB-mediated NADPH oxidase-2 upregulation

CONCLUSIONS: These findings indicate that 1) CnAα loss stimulates Nox2 upregulation, 2) NFκB is a novel CnAα-regulated transcription factor and 3) NFκB mediates CnAα-induced Nox2 and ROS upregulation.SIGNIFICANCE: Our results demonstrate that CnAα plays a key role in Nox2 and ROS generation. Further, these novel findings provide evidence of divergent CnA isoform signaling pathways. Finally, this study advocates for CnAα-sparing CNIs, ultimately circumventing the CNI nephrotoxicity.PMID:33615888 | DOI:10.1152/ajprenal.00254.2020

Source: American Journal of Physiology. Renal Physiology - February 22, 2021 Category: Physiology Authors: Aswathy M Cheriyan Adaku C Ume Cynthia E Francis Keyona N King Valerie A Linck Yun Bai Hui Cai Robert S Hoover Heping P Ma Jennifer L Gooch Clintoria R Williams Source Type: research