Soluble fms-like tyrosine kinase-1 and angiotensin2 target CALCB family peptides in maternal vascular smooth muscle cells in pregnancy

CONCLUSION: sFLT-1 and Ang2 impair OASMC mediated functional responses of CALCB family peptides which can be inhibited by respective peptide treatment. The sensitivity of OA for CALCB, ADM and ADM2-mediated relaxation is retained in PE.PMID:33624744 | DOI:10.1093/biolre/ioab026

Source: Biology of Reproduction - February 24, 2021 Category: Reproduction Medicine Authors: Madhu Chauhan Ancizar Betancourt Meena Balakrishnan Akansha Mishra Karin Fox Michael Belfort Chandra Yallampalli Source Type: research