A bioinspired oxoiron(IV) motif supported on a N < sub > 2 < /sub > S < sub > 2 < /sub > macrocyclic ligand

Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00250c. Online ahead of print.ABSTRACTA mononuclear oxoiron(iv) complex 1-trans bearing two equatorial sulfur ligations is synthesized and characterized as an active-site model of the elusive sulfur-ligated FeIV[double bond, length as m-dash]O intermediates in non-heme iron oxygenases. The introduction of sulfur ligands weakens the Fe[double bond, length as m-dash]O bond and enhances the oxidative reactivity of the FeIV[double bond, length as m-dash]O unit with a diminished deuterium kinetic isotope effect, thereby providing a compelling rationale for nature's use of the cis-thiolate ligated oxoiron(iv) motif in key metabolic transformations.PMID:33621306 | DOI:10.1039/d1cc00250c

Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Jennifer Deutscher Philipp Gerschel Katrin Warm Uwe Kuhlmann Stefan Mebs Michael Haumann Holger Dau Peter Hildebrandt Ulf-Peter Apfel Kallol Ray Source Type: research