Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts

CONCLUSION: Hypoxia and P. gingivalis-LPS synergistically induced NLRP3 inflammasome activation in HGFs, and subsequently high levels of interleukin-1β and GSDMD-mediated pyroptosis can cause an HGF inflammatory response, which plays an important role in the pathogenesis of periodontitis.PMID:33588175 | DOI:10.1016/j.intimp.2021.107456

Source: International Immunopharmacology - February 15, 2021 Category: Allergy & Immunology Authors: Kai Yang Shuo Xu Hongmei Zhao Lingshuang Liu Xiaofang Lv Fang Hu Lei Wang Qiuxia Ji Source Type: research