Calcineurin A-alpha suppression drives Nuclear Factor κB-mediated NADPH oxidase-2 upregulation.

CONCLUSIONS: These findings indicate that 1) CnAα loss stimulates Nox2 upregulation, 2) NFκB is a novel CnAα-regulated transcription factor and 3) NFκB mediates CnAα-induced Nox2 and ROS upregulation.
SIGNIFICANCE: Our results demonstrate that CnAα plays a key role in Nox2 and ROS generation. Further, these novel findings provide evidence of divergent CnA isoform signaling pathways. Finally, this study advocates for CnAα-sparing CNIs, ultimately circumventing the CNI nephrotoxicity.
PMID: 33615888 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - February 22, 2021 Category: Physiology Authors: Cheriyan AM, Ume AC, Francis CE, King KN, Linck VA, Bai Y, Cai H, Hoover RS, Ma HP, Gooch JL, Williams CR Tags: Am J Physiol Renal Physiol Source Type: research