GSE162966 IL11 is elevated in systemic sclerosis and IL11-dependent ERK signaling is needed for the profibrotic activity of TGF β in dermal fibroblasts

Conclusions: These data reveal an important contribution of IL11-related ERK activity for TGF β-stimulated fibrosis phenotypes in HDFs and suggest IL11 as a potential therapeutic target in SSc.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research