Altered parvalbumin basket cell terminals in the cortical visuospatial working memory network in schizophrenia

Visuospatial working memory (vsWM), which is commonly impaired in schizophrenia, involves information processing across primary visual (V1), association visual (V2), posterior parietal (PPC), and dorsolateral prefrontal (DLPFC) cortices. Within these regions, vsWM requires inhibition from parvalbumin (PV)-expressing basket cells (PVBCs). Here, we analyzed indices of PVBC axon terminals across regions of the vsWM network in schizophrenia.

Source: Biological Psychiatry - February 18, 2021 Category: Psychiatry Authors: Kenneth N. Fish, Brad R. Rocco, Adam M. DeDionisio, Samuel J. Dienel, Robert A. Sweet, David A. Lewis Tags: Archival Report Source Type: research