Intravenous prostacyclin-analogue therapy in pulmonary arterial hypertension – a review of the past, present and future

Therapy with intravenous prostacyclin analogues in patients with pulmonary arterial hypertension (PAH) has been established for decades and is an integral component of the current guidelines for the treatment of pulmonary hypertension.Initially, these drugs were infused by external pump systems via tunnelled right atrial catheters with the need for cooling and frequent exchange of drug reservoirs. Associated complications included, among others, catheter-related infections.More recently, fully implantable pump systems have been developed with drug reservoirs that are filled transcutaneously, allowing intervals between refills of several weeks.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Original Research Source Type: research