Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts.

CONCLUSION: Hypoxia and P. gingivalis-LPS synergistically induced NLRP3 inflammasome activation in HGFs, and subsequently high levels of interleukin-1β and GSDMD-mediated pyroptosis can cause an HGF inflammatory response, which plays an important role in the pathogenesis of periodontitis.
PMID: 33588175 [PubMed - as supplied by publisher]

Source: International Immunopharmacology - February 12, 2021 Category: Allergy & Immunology Authors: Yang K, Xu S, Zhao H, Liu L, Lv X, Hu F, Wang L, Ji Q Tags: Int Immunopharmacol Source Type: research