Strain ‐Level Immunomodulatory Variation of Gut Bacteria

AbstractThe gut microbiota and the immune system have co ‐evolved to interact and cooperate in many ways. A recent study characterizing the immunomodulatory effects of over 60 different human‐derived gut microbes across phyla showed that bacteria‐induced immunomodulations are not dictated by the bacterial phylogeny. Yet, it remains unclear whether s trains from the same species induce the same immunomodulatory effects on the host. We analyzed the strain‐level data from this recent study and found that strains from the same species can induce distinct and sometimes even opposing immunophenotypes. Hence, we suggest that the immunomodulatory cap abilities of gut bacteria can be strain‐specific.

Source: FEBS Letters - February 11, 2021 Category: Biochemistry Authors: Haitham Hajjo, Naama Geva ‐Zatorsky Tags: RESEARCH LETTER Source Type: research