The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: A narrative review of human GLP-1 receptor antagonist studies
The bariatric procedures Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiological importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Morten Hinds ø, Maria S. Svane, Nora Hedbäck, Jens J. Holst, Sten Madsbad, Kirstine N. Bojsen-Møller Source Type: research
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