The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: A narrative review of human GLP-1 receptor antagonist studies

The bariatric procedures Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiological importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research