Screening tools for hereditary hemolytic anemia: new concepts and strategies.

Screening tools for hereditary hemolytic anemia: new concepts and strategies.
Expert Rev Hematol. 2021 Feb 05;:
Authors: Fermo E, Vercellati C, Bianchi P
Abstract
INTRODUCTION: Hereditary haemolytic anemias are a group of rare and heterogeneous disorders due to abnormalities in structure, metabolism and transport functions of erythrocytes; they may overlap in clinical and haematological features making differential diagnosis difficult, particularly in mild and atypical forms.
AREAS COVERED: In the present review the main tools currently adopted in routine hematologic investigation for the diagnosis of hereditary hemolytic anemias are described, together with the new diagnostic approaches that are being to be developed in the next future. Available recommendations in this field together with a systematical review through MEDLINE, EMBASE, and PubMED for publications in English from 2000 to 2020 in regards to diagnostic aspects of hereditary hemolytic anemias have been considered.
EXPERT OPINION: The recent development of specific molecules and treatments for hereditary haemolytic anemias and the increased interest in translational research raised the attention on differential diagnosis and the demand for novel diagnostic assays and devices. Automatic blood cell analysers, omic-approaches including NGS technologies, and development of new automated tools based on artificial neural networks definitely represent the future...

Source: Expert Review of Hematology - February 7, 2021 Category: Hematology Tags: Expert Rev Hematol Source Type: research