Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in preeclampsia: a genetic and functional study.

CONCLUSIONS: Results suggest that changes in complement-facilitated phagocytosis are associated with preeclampsia. Further studies are needed to ascertain, whether aberrant CR3 and CR4 activity leads to altered pro- and anti-inflammatory cytokine responses in individuals carrying the associating variants and the role of these receptors in preeclampsia pathogenesis.
PMID: 33539617 [PubMed - as supplied by publisher]

Source: BJOG : An International Journal of Obstetrics and Gynaecology - February 4, 2021 Category: OBGYN Authors: Lokki AI, Teirilä L, Triebwasser M, Daly E, Bhattacharjee A, Uotila L, Llort Asens M, Kurki MI, Perola M, Auro K, Salmon JE, Daly M, Atkinson JP, Laivuori H, Fagerholm S, Meri S, Finnpec Tags: BJOG Source Type: research