Management of multiple brain metastases via dual-isocenter VMAT stereotactic radiosurgery

Single-isocenter volumetric modulated arc therapy (VMAT) stereotactic radiosurgery (SRS) techniques to treat multiple brain metastases simultaneously can significantly improve treatment delivery efficiency, patient compliance, and clinic workflow. However, due to large number of brain metastases sharing the same MLC pair causing island blocking, there is higher low- and intermediate-dose spillage to the normal brain and higher dose to organs-at-risk (OAR). To minimize this problem and improve plan quality, this study proposes a dual-isocenter planning strategy that groups lesions based on hemisphere location (left vs right sided) in the brain parenchyma, providing less island blocking reducing the MLC travel distance.

Source: Medical Dosimetry - February 3, 2021 Category: Radiology Authors: Allison N Palmiero, Denise Fabian, William St Clair, Marcus Randall, Damodar Pokhrel Source Type: research