Vitamin D receptor regulates TGF-{beta} signalling in systemic sclerosis

Conclusions
We characterise VDR as a negative regulator of TGF-β/Smad signalling. Impaired VDR signalling with reduced expression of VDR and decreased levels of its ligand may thus contribute to hyperactive TGF-β signalling and aberrant fibroblast activation in SSc.

Source: Annals of the Rheumatic Diseases - February 5, 2015 Category: Rheumatology Authors: Zerr, P., Vollath, S., Palumbo-Zerr, K., Tomcik, M., Huang, J., Distler, A., Beyer, C., Dees, C., Gela, K., Distler, O., Schett, G., Distler, J. H. W. Tags: Connective tissue disease Basic and translational research Source Type: research