Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)-PLUS

Condition:   Multidrug Resistant Tuberculosis Intervention:   Drug: PZA sensitivity guided ultra-short all oral Regimen Sponsor:   Huashan Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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[Independent (Kampala)] Early diagnosis is crucial for the effective management of any disease. In Africa, this is not always possible which affects the ability of countries to bring diseases under control.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Int J Nephrol Renovasc Dis. 2021 Sep 7;14:359-369. doi: 10.2147/IJNRD.S236552. eCollection 2021.ABSTRACTXanthogranulomatous Pyelonephritis (XGP) is a rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response resulting in focal or diffuse renal destruction. This destruction may be profound with the potential to infiltrate surrounding tissues and viscera. The imaging features of XGP can be ambiguous, mimicking malignancy, tuberculosis (TB) and malakoplakia earning the title of "the great imitator". C...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Authors: Source Type: research
[UCT] Low Vitamin D levels have been hypothesised by some experts to be a risk factor for tuberculosis (TB). People who develop TB often present with low Vitamin D levels when they are diagnosed. However, whether Vitamin D levels at one point predispose a child to developing TB is debated and not clear.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Conclusions: Depletion of PD-1/PD-L1 pathway did not affect the activation of Th1 immunity in response to MAC infection, which may explain why MAC infection was controlled in these mice. In addition, CD8-positive T cell pulmonary inflammation in knockout mice might have some clinical implication in the treatment of cancer patients with immune checkpoint inhibitors when the patients are infected with MAC.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Lipid metabolism plays a complex and dynamic role in host-pathogen interaction during Mycobacterium tuberculosis infection. While bacterial lipid metabolism is key to the success of the pathogen, the host also offers a lipid rich environment in the form of necrotic caseous granulomas, making this association beneficial for the pathogen. Accumulation of the neutral lipid triglyceride, as lipid droplets within the cellular cuff of necrotic granulomas, is a peculiar feature of pulmonary tuberculosis. The role of triglyceride synthesis in the TB granuloma and its impact on the disease outcome has not been studied in detail. He...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
[WHO-AFRO] The Green Light Committee (GLC) Initiative, together with the Working Group on MDR-TB, promotes implementation of the component two of the Stop TB Strategy that calls for the control and prevention of multidrug-resistant tuberculosis (MDR-TB) through: (i) increased access to quality-assured second-line anti-TB drugs; and (ii) prevention of development of resistance to anti-TB drugs in accordance with the Global Plan to Stop TB (2006-2015) and the Global MDR/XDR-TB Response plan (2007-2008).
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Source Type: research
J Korean Med Sci. 2021 Sep 13;36(36):e246. doi: 10.3346/jkms.2021.36.e246.ABSTRACTIn 2017, the Korean government launched an unprecedentedly large-scaled latent tuberculosis infection (LTBI) screening project which covered more than a million individuals in congregate settings. A total of 1,047,689 participants of source population (n = 2,336,157) underwent LTBI testing from 2017 to 2018. The overall LTBI test uptake rate during this project was 44.8%. Workers in daycare centers (83.5%) and kindergartens (78.9%) showed high participation rate. A total of 1,012,206 individuals with valid results of interferon-gamma release ...
Source: J Korean Med Sci - Category: General Medicine Authors: Source Type: research
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
This study aimed to evaluate the incidence of Tuberculosis (TB) among prisoners in Iran, by performing a systematic and meta-analysis study on the related articles.METHODOLOGY: Scopus, Iran doc, Cochrane, Pubmed, Medline, Embase and Iran Medex, Magiran, SID, Google Scholar, and EBSCO were searched. After quality assessment of the articles, a fixed or random model, as appropriate, was used to pool the results in a meta-analysis. Heterogeneity between the studies was assessed using I-square and Q-test.RESULTS: The overall sample size of included studies was 19562 that 64 of them were with TB. The highest prevalence of tuberc...
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Source Type: research
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