Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma

ConclusionSimilar variant allele frequencies ofFGFR1 p.K656E andFGFR1 p.V561M mutations in our patient's tumor suggest that these mutations may have occurred at similar time points. Use of FGFR inhibitors in addition to STAT3 or PI3K/mTOR inhibition may prove a useful strategy in targeting our patient's pilomyxoid astrocytoma.

Source: Molecular Genetics & Genomic Medicine - January 14, 2021 Category: Genetics & Stem Cells Authors: Elena I. Fomchenko, Benjamin C. Reeves, William Sullivan, Asher M. Marks, Anita Huttner, Kristopher T. Kahle, E. Zeynep Erson ‐Omay Tags: CLINICAL REPORT Source Type: research