Chronic lymphocytic leukemia –like monoclonal B-cell lymphocytosis exhibits an increased inflammatory signature that is reduced in early-stage chronic lymphocytic leukemia

Several alterations have been described in T cells of patients with chronic lymphocytic leukemia (CLL), presumably a consequence of chronic exposure to tumor cells [1 –8]. Additionally, an elevated number of monocytes have been detected in peripheral blood (PB) of patients with the disease, exhibiting deregulated genes involved in phagocytosis and inflammation [9]. Serum cytokine levels have also been described to be altered in CLL [10], and increased levels of some cytokines such as CC chemokine ligand 3 (CCL3 and IL8 have been associated with a worse outcome [11,12].

Source: Experimental Hematology - January 6, 2021 Category: Hematology Authors: Gonzalo Blanco, Anna Puiggros, Barbara Sherry, Lara Nonell, Xavier Calvo, Eul àlia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, Gerardo Ferrer, Florencia Palacios, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, Eugènia Abella, Kanti R. Rai, Pau Abr Source Type: research