Factors affecting long-lasting pain relief after Gamma Knife radiosurgery for trigeminal neuralgia: a single institutional analysis and literature review

AbstractGamma Knife radiosurgery (GKRS) is a well-established safe and effective treatment for trigeminal neuralgia (TN) with high initial success rate (80 –90%). Why the pain relief is progressively decreased with time is a matter of considerable debate. To investigate factors related to long-lasting pain relief, the authors conducted a retrospective analysis focusing on anatomical and radiosurgical related parameters, chosen according to literature review. One hundred and twelve patients with classical trigeminal neuralgia and follow-up longer than 12 months were selected from our institutional consecutive series of patients treated by GKRS. Patients were followed for a mean period of 61.5 ± 3.5 months (range, 12–126 months) to evaluate, a s endpoints, long-term pain relief and hypoesthesia onset. The median maximum radiation dose was 80 Gy (range 70–90 Gy). Factors related to poor long-term pain relief were prescription dose< 80 Gy (p = 0.038), calibration dose rate< 2.5 Gy/min (p = 0.018), and distance between isocenter and trigeminal nerve emergence> 8 mm (p< 0.001). When analyzing patients who received 80 Gy as maximum dose without any sector blocking, we notice that ID50< 2.7 mJ was predictive for longer period of pain control (p = 0.043). It was experienced also among patients in which a small volume of the nerve (< 35%) received more than 80% of the maximal dose, compared to those in which a larger volume of the nerve was irradiated with maxi...

Source: Neurosurgical Review - January 12, 2021 Category: Neurosurgery Source Type: research