Circulating biomarkers of nitric oxide bioactivity and impaired muscle vasoreactivity to exercise in adults with uncomplicated type 1 diabetes

Conclusions/interpretationParticipants with uncomplicated type 1 diabetes displayed reduced availability ofl-arginine, the essential substrate for enzymatic nitric oxide synthesis, as well as lower levels of the major plasma antioxidant, urate. Lower urate levels may reflect a defect in the activity of xanthine oxidase, an enzyme capable of producing NO from nitrite under hypoxic conditions. Thus, both canonical and non-canonical NO production may be reduced. However, neither of these changes exacerbated exercise-induced oxidative stress.Trial registrationclinicaltrials.gov NCT02051504

Source: Diabetologia - January 11, 2021 Category: Endocrinology Source Type: research