Factors affecting the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus in preterm infants

Conclusion A single course of oral ibuprofen for patent ductus arteriosus closure among preterm infants is effective and safe. Preterm infants with postnatal age of ≤ 9 days at the initiation of treatment and Day 1/Day 0 ratio of ≤ 0.708 of the urine output/fluid intake during the treatment course can be considered predictors of effectiveness of patent ductus arteriosus.
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research