NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity

Capsule Summary: Genetic deletion of Nlrp1 in mice and the M1184V variant in humans both exacerbate asthmatic pathology, consistent with the mechanism of activation being related to DPP9 inhibition.

Source: Journal of Allergy and Clinical Immunology - December 27, 2020 Category: Allergy & Immunology Authors: Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, Marquitta J. White, Cassandra R. Harapas, Chien-Hsiung Yu, Sophia Davidson, Katja Hrovat Schaale, Donglei Hu, Celeste Eng, Scott Huntsman, Dale J. Calleja, Jay C. Horvat, Phil M. Hansbro, Robert J.J. Source Type: research