Depression and the Risk of Fractures in Later Life: the Health In Men Cohort Study

Depression is a leading cause of disability worldwide that affects people of all ages [1]. Its presence hinders recovery from other health conditions [2] and has been associated with increased risk of hazardous health events. Several studies have reported that a greater proportion of people with depression than without depression will have a bone fracture [3,4], although there is marked heterogeneity among published studies [4] and the possible role of confounding remains unclear. For example, people with depression are more likely to use antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs), which have been shown to increase the risk of fractures in observational studies [5] and placebo-controlled randomised trials of stroke survivors [6].
Source: Maturitas - Category: Primary Care Authors: Source Type: research