Mechanisms and Control Strategies of Antibiotic Resistance in Pathological Biofilms.

Mechanisms and Control Strategies of Antibiotic Resistance in Pathological Biofilms. J Microbiol Biotechnol. 2020 Dec 07;: Authors: Luo Y, Yang Q, Zhang D, Yan W Abstract Bacterial biofilm is a community of bacteria that are embedded and structured in self-secreted extracellular matrix. An important clinical-related characteristic of bacterial biofilms is that they are much more resistant to antimicrobial agents than the planktonic cells (up to 1000 times), which is one of the main causes of antibiotic resistance in clinics. Therefore, infections caused by biofilms are notoriously difficult to eradicate, such as lung infection caused by Pseudomonas aeruginosa in cystic fibrosis patients. Understanding mechanisms of resistance of biofilms will provide direct insights to how we overcome such resistance. In this review, we summarized the characteristics of biofilms and chronic infections associated with bacterial biofilms. We reviewed the current understanding and research progress on the major mechanisms of antibiotic resistance in biofilms, including quorum sensing. We also reviewed the potential strategies that may overcome biofilm-related antibiotic resistance, focusing on targeting the EPS of biofilm, blocking quorum sensing signaling, and using recombinant phages. PMID: 33323672 [PubMed - as supplied by publisher]
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research