Phenformin: AMP(K)ed for Potential Repurposing
The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through which phenformin may exert its antitumorigenic effect are desc ribed. Thus, the proposed repurposing of phenformin to treat skin cancer has merit.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Joo Jung, Wendy B. Bollag Tags: Commentary Source Type: research