A proteomics-based assessment of inflammation signatures in endotoxemia.

In conclusion, the rise in multimeric PTX3 upon LPS injection correlates with neutrophil-related protein changes in plasma and in aortas. MPO and myeloid Nox2 are not required for the multimerisation of PTX3; instead, neutrophil extravasation is responsible for the LPS-induced deposition of multimeric PTX3 in the aorta. PMID: 33288685 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33288685?dopt=Abstract

Source: Molecular and Cellular Proteomics : MCP - December 7, 2020 Category: Molecular Biology Authors: Burnap SA, Mayr U, Shankar-Hari M, Cuello F, Thomas MR, Shah AM, Sabroe I, Storey RF, Mayr M Tags: Mol Cell Proteomics Source Type: research

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