Impaired interferon ‐α expression in plasmacytoid dendritic cells in asthma

ConclusionOur study discovered the response to TLR ‐7 stimulation in pDCs was compromised and the sustainability of interferon‐α expression to RV stimulation was reduced in pDCs of asthmatic patients, which provide further evidence of defective innate response and subspeciality to RV infection in asthma. The high exacerbation history founded in RV+ patients agrees with these findings. Further research is required for the modulatory effect of IL‐4 on TLR‐7 stimulated pDCs.

Source: Immunity, Inflammation and Disease - November 25, 2020 Category: Allergy & Immunology Authors: Ting ‐Yu Lin, Chun‐Yu Lo, Kuo‐Chien Tsao, Po‐Jui Chang, Chih‐His Scott Kuo, Yu‐Lun Lo, Shu‐Min Lin, Meng‐Heng Hsieh, Tsai‐Yu Wang, Ping‐Chih Hsu, Horng‐Chyuan Lin Tags: ORIGINAL RESEARCH Source Type: research